Airway and Gut Immune Recruitment Models

The airway and gut epithelium act as both physical barriers to pathogens and pollutants and as active regulators of immune responses that shape disease progression. These responses vary widely across diseases and individuals, limiting the predictive power of molecular biomarkers alone. To address this, we develop advanced in vitro models that recreate the full immune response, from pathogen entry to immune cell recruitment, enabling functional and quantitative assessment of immune dynamics and therapeutic responses in airway and gut tissues.

Highlight 1: Airway Immune Recruitment and Machine Learning

We have developed a novel immune recruitment device featuring a central channel with an air-liquid-interface for bronchial cells, flanked by two immune cell channels. These are linked by microchannels which allow us to track immune recruitment using our machine learning model.