Multi-Organ Co-Culture Systems
We are interested in modelling systemic multi-cellular or tissue interactions, and using these platforms to study drug responses and diseases in scalable formats.
Highlight 1: LM-Well Insert for Patterning Local Microenvironments in Well Plates
Our group is interested in the use of open microfluidics to generate accessible, simple OoCs. We have developed a 3D-printed well-insert capable of patterning multiple cell-laden hydrogel niches in a single well of a traditional well plate. This is making previously technically challenging co-cultures possible in a simple format, and the study of inter-niche interactions more accessible.
Highlight 2: Engineered Micro-Biosystems for Microbiome Research
The gut microbiome, the community of microorganisms and their genes in the gastrointestinal tract, plays a central role in human health. When this ecosystem is disrupted, it is linked to many diseases. Although modern “omics” technologies have identified strong links between microbiome composition and disease, functional models are still needed to understand how specific microbes behave and interact with the human gut.
Our project meets this need by developing gut microphysiological systems (MPS) that replicate key intestinal physiological functions in a format suitable for routine experiments and screening. Because most gut microbes require oxygen-free conditions, we engineer platforms that combine an oxygenated intestinal lining with an anaerobic microbial compartment. In parallel, we develop human intestinal disease models that reproduce barrier function, mucus production, and inflammatory responses, enabling more accurate predictions of how microbes influence human health and disease.
Highlight 3: Sensor Integration into Multi-Organ Platforms
We are developing electrochemical aptamer-based biosensors integrated into microphysiological systems to provide continuous, real-time readouts of cellular function. This approach overcomes destructive endpoint assays, enabling dynamic assessment of drug efficacy and toxicity in human-relevant in vitro models.
