Multi-organ systemic interactions, such as in microbiome-host crosstalk and metabolic diseases, epitomise the complexity of human physiology. This project seeks to overcome the engineering challenges of customising, synchronising and connecting multiple tissues in a flexible format to depict multi-organ interactions using modular microfluidics and advanced bio-fabrication technologies.

Retrofitting different microfluidic devices into functional modules that can reversibly connect to each other planarly

Generation of different human tissue modules

Demonstrating liver-endothelium crosstalk: anti-inflammatory effects of nutraceutical (Quercetin) on endothelium is enhanced with liver bioactivation